SCHEMBL6965217

SCHEMBL6965217

CCOC(=O)C=Cc1cc2ccccc2s1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.47
CYP3A4 P08684 2/20 0.47
CCNC P24863 1/20 0.47
CDK8 P49336 1/20 0.47
TTR P02766 1/20 0.46
DPP4 P27487 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
TUBB4A P04350 2/20 0.45
TUBB P07437 2/20 0.45
TUBA3C P0DPH7 2/20 0.45
TUBA1B P68363 2/20 0.45
TUBA4A P68366 2/20 0.45
TUBB4B P68371 2/20 0.45
TUBB3 Q13509 2/20 0.45
TUBB2A Q13885 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965215 1.00 CYP2A6 (0.47) CYP2A6CYP3A4CCNCCDK8TTR
SCHEMBL12809271 0.84 CYP2A6 (0.51) CYP2A6CCNCCDK8TTRCA12
SCHEMBL28874860 0.84 CYP2A6 (0.51) CYP2A6CCNCCDK8TTRCA12
SCHEMBL6964344 0.83 IDO1 (0.43) CYP3A4CCNCCDK8TTRDPP4
SCHEMBL6964345 0.83 IDO1 (0.43) CYP3A4CCNCCDK8TTRDPP4
SCHEMBL6965431 0.83 MAPT (0.44) CYP2A6CYP3A4TTRDPP4CA12
SCHEMBL29709927 0.83 TTR (0.43) CYP2A6CYP3A4CCNCCDK8TTR
SCHEMBL6965434 0.83 MAPT (0.44) CYP2A6CYP3A4TTRDPP4CA12
SCHEMBL1903001 0.81 CYP2A6 (0.47) CYP2A6CYP3A4TUBB4ATUBBTUBA3C
SCHEMBL1903000 0.81 CYP2A6 (0.47) CYP2A6CYP3A4TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974584-B1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-01-15 EP disclosed
US-6420375-B1 ANTITUMOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-16 US disclosed
EP-0974584-A1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-01-26 EP disclosed
US-5128448-A Peptide hormones HOFFMAN-LA ROCHE INC. (US) 1992-07-07 US disclosed