Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1402982 | 0.88 | GAA (0.49) | MAPTALDH1A1NPC1POLBLMNA | |
| SCHEMBL12809444 | 0.83 | NPC1 (0.38) | MAPTALDH1A1NPC1POLBNPSR1 | |
| SCHEMBL1403420 | 0.79 | ABHD6 (0.49) | MAPTALDH1A1NPSR1LMNAKMT2A | |
| SCHEMBL1403236 | 0.77 | NPC1 (0.56) | ALDH1A1NPC1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1402730 | 0.74 | GAA (0.42) | MAPTALDH1A1NPC1POLBLMNA | |
| SCHEMBL13124004 | 0.74 | GAA (0.49) | ALDH1A1NPC1POLBLMNAKMT2A | |
| SCHEMBL8563045 | 0.72 | CA12 (0.50) | MAPTALDH1A1NPC1HTTKMT2A | |
| SCHEMBL1402579 | 0.68 | MAPT (0.52) | MAPTALDH1A1NPSR1HTTLMNA | |
| SCHEMBL27700413 | 0.67 | KMT2A (0.57) | MAPTALDH1A1NPC1HTTLMNA | |
| SCHEMBL1403039 | 0.67 | TP53 (0.41) | MAPTALDH1A1NPC1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292228-A1 | Pyrazole derivatives as 11-beta-HSD1 inhibitors | AstraZeneca AB (Publ) (SE) | 2011-03-09 | — | — | EP | disclosed |