Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135380 | 0.84 | KMT2A (0.53) | KMT2ARIPK1RIPK3MAPTSMN1; SMN2 | |
| SCHEMBL4745549 | 0.83 | ALDH1A1 (0.50) | KMT2ARIPK1RIPK3MAPTSMN1; SMN2 | |
| SCHEMBL19085086 | 0.82 | MTNR1A (0.47) | RIPK1RIPK3MAPTSMN1; SMN2MTNR1A | |
| SCHEMBL4961300 | 0.81 | MTNR1A (0.47) | KMT2ARIPK1RIPK3MAPTSMN1; SMN2 | |
| SCHEMBL5042255 | 0.81 | KMT2A (0.67) | KMT2AMAPTSMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL9895432 | 0.81 | CA12 (0.53) | KMT2AMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2650122 | 0.80 | LOXL2 (0.54) | KMT2ARIPK1RIPK3MAPTSMN1; SMN2 | |
| SCHEMBL15955709 | 0.79 | KMT2A (0.60) | KMT2AMAPTSMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL13308118 | 0.79 | CYP4F2 (0.47) | KMT2ARIPK1RIPK3MAPTRAB9A | |
| SCHEMBL1283948 | 0.79 | CA2 (0.50) | RIPK1RIPK3MTNR1AMTNR1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102127023-B | 7-membered ring compound, process for producing the same, and use thereof | DAIICHI SANKYO CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-102127023-A | 7-membered ring compound, process for producing the same, and use thereof | DAIICHI ASUBIO PHARMA CO LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-101160290-B | 7-membered ring compound, process for producing the same, and pharmaceutical use thereof | DAIICHI SANKYO CO LTD | 2011-01-19 | — | — | CN | disclosed |
| CN-101495463-A | Seven-membered ring compound, production method thereof and pharmaceutical use thereof | ASUBIO PHARMA CO LTD (JP) | 2009-07-29 | — | — | CN | disclosed |
| CN-101160290-A | 7-membered ring compound, process for producing the same, and pharmaceutical use thereof | ASUBIO PHARMA CO LTD (JP) | 2008-04-09 | — | — | CN | disclosed |