Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809582 | 1.00 | HTT (0.39) | HTTLMNACNR2HSD11B1HSD17B10 | |
| SCHEMBL12809710 | 0.99 | HTT (0.40) | HTTLMNACNR2HSD11B1HSD17B10 | |
| SCHEMBL12809748 | 0.92 | HRH4 (0.41) | HTTLMNAHSD11B1HSD17B10MEN1 | |
| SCHEMBL12809749 | 0.91 | LMNA (0.39) | HTTLMNACNR2HSD11B1HSD17B10 | |
| SCHEMBL12809750 | 0.90 | ALDH1A1 (0.41) | HTTLMNACNR2HSD11B1HSD17B10 | |
| SCHEMBL12809703 | 0.90 | LMNA (0.38) | HTTLMNAHSD11B1HSD17B10MEN1 | |
| SCHEMBL12809575 | 0.88 | IDH1 (0.37) | HTTLMNACNR2HSD11B1HSD17B10 | |
| SCHEMBL14412764 | 0.87 | HTT (0.36) | HTTLMNAHSD11B1HSD17B10MEN1 | |
| SCHEMBL12809759 | 0.87 | CNR2 (0.37) | LMNACNR2HSD11B1HSD17B10MEN1 | |
| SCHEMBL12809585 | 0.87 | HTT (0.38) | HTTLMNACNR2HSD11B1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |