Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809580 | 1.00 | HTT (0.38) | HTTHSD11B1LMNAHSD17B10CNR2 | |
| SCHEMBL12809747 | 0.86 | HTT (0.49) | HTTHSD11B1LMNAHSD17B10CNR2 | |
| SCHEMBL12809450 | 0.85 | HSD11B1 (0.44) | HTTHSD11B1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL12809739 | 0.85 | HSD11B1 (0.44) | HTTHSD11B1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL12809586 | 0.84 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL12809752 | 0.83 | CNR2 (0.35) | HSD11B1LMNAHSD17B10CNR2MEN1 | |
| SCHEMBL14413254 | 0.83 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL12809455 | 0.83 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL1406827 | 0.83 | HTT (0.55) | HTTHSD11B1LMNAALDH1A1HPGD | |
| SCHEMBL12809759 | 0.83 | CNR2 (0.37) | HSD11B1LMNAHSD17B10CNR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |