Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809759 | 0.99 | CNR2 (0.37) | CNR2HSD11B1LMNATYK2MEN1 | |
| SCHEMBL12809589 | 0.92 | HSD11B1 (0.34) | HSD11B1LMNAMEN1KMT2AHSD17B10 | |
| SCHEMBL12809574 | 0.89 | HSD11B1 (0.33) | HSD11B1LMNAMEN1KMT2AHSD17B10 | |
| SCHEMBL12809710 | 0.87 | HTT (0.40) | CNR2HSD11B1LMNATYK2MEN1 | |
| SCHEMBL12809702 | 0.86 | HTT (0.39) | CNR2HSD11B1LMNATYK2MEN1 | |
| SCHEMBL12809582 | 0.86 | HTT (0.39) | CNR2HSD11B1LMNATYK2MEN1 | |
| SCHEMBL1407012 | 0.84 | HSD11B1 (0.48) | CNR2HSD11B1LMNA | |
| SCHEMBL12809588 | 0.83 | HSD11B1 (0.39) | HSD11B1LMNATYK2HSD17B10 | |
| SCHEMBL12809751 | 0.83 | HSD11B1 (0.39) | HSD11B1LMNATYK2HSD17B10 | |
| SCHEMBL12809778 | 0.83 | HTT (0.38) | CNR2HSD11B1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |