Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2519868 | 0.81 | ALDH1A1 (0.54) | ALDH1A1CYP3A4TLR8POLBNR4A2 | |
| SCHEMBL18283411 | 0.81 | NR4A2 (0.46) | ALDH1A1CYP3A4TLR8POLBNR4A2 | |
| SCHEMBL5765299 | 0.80 | NR4A2 (0.58) | ALDH1A1CYP3A4TLR8NR4A2SOS2 | |
| SCHEMBL15111036 | 0.79 | NR4A2 (0.43) | ALDH1A1CYP3A4TLR8POLBNR4A2 | |
| SCHEMBL18283482 | 0.79 | NR4A2 (0.43) | ALDH1A1CYP3A4TLR8POLBNR4A2 | |
| SCHEMBL28467228 | 0.78 | GAK (0.46) | ALDH1A1CYP3A4POLBMAPTRXFP1 | |
| SCHEMBL11704085 | 0.77 | ALDH1A1 (0.47) | ALDH1A1CYP3A4TLR8POLBNR4A2 | |
| SCHEMBL11062749 | 0.76 | CYP3A4 (0.43) | ALDH1A1CYP3A4TLR8NR4A2SOS2 | |
| SCHEMBL25953825 | 0.76 | TLR8 (0.51) | ALDH1A1TLR8MPO | |
| SCHEMBL15801275 | 0.75 | PARP1 (0.45) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647677-B2 | Analogues of hydroxychloroquine (HCQ) without retinal toxicity | INOVIEM SCIENTIFIC (FR) | 2020-05-12 | — | — | US | disclosed |
| EP-1807421-B1 | 2-AMIDO-4-PHENYLTHIAZOLE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2011-03-16 | — | — | EP | disclosed |
| US-7598392-B2 | 2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-10-06 | — | — | US | disclosed |
| US-7598392-B2 | 2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-10-06 | — | — | US | disclosed |
| US-20070259847-A1 | 2-Amido-4-phenylthiazole Derivatives, The Preparation And The Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2007-11-08 | — | — | US | disclosed |
| US-20070259847-A1 | 2-Amido-4-phenylthiazole Derivatives, The Preparation And The Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647677-B2 | Analogues of hydroxychloroquine (HCQ) without retinal toxicity | SSB, UACA, XPA | ALDH1A1 1358/4885CYP3A4 1361/4885TLR8 1443/4885 |
| US-20070259847-A1 | 2-Amido-4-phenylthiazole Derivatives, The Preparation And The Therapeutic Use Thereof | PKD2, TPMT, PKD1 | ALDH1A1 950/4885CYP3A4 45/4885TLR8 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.