Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13539401 | 0.92 | TAS1R3 (0.37) | TAS1R3TAS1R1METAP2HRH3KDM4E | |
| SCHEMBL3457241 | 0.89 | TAS1R3 (0.39) | TAS1R3TAS1R1METAP2HRH3KDM4E | |
| SCHEMBL3457248 | 0.89 | TAS1R3 (0.39) | TAS1R3TAS1R1METAP2HRH3KDM4E | |
| SCHEMBL19217096 | 0.84 | SAE1 (0.37) | TAS1R3TAS1R1METAP2HRH3KDM4E | |
| SCHEMBL8203526 | 0.79 | ITGB3 (0.41) | ALDH1A1KMT2ASMN1; SMN2KDM1AMEN1 | |
| SCHEMBL19723075 | 0.79 | ITGB3 (0.41) | ALDH1A1KMT2ASMN1; SMN2KDM1AMEN1 | |
| SCHEMBL1410826 | 0.77 | TAS1R3 (0.36) | TAS1R3TAS1R1METAP2HRH3KMT2A | |
| SCHEMBL1410827 | 0.77 | TAS1R3 (0.39) | TAS1R3TAS1R1METAP2KDM4EALDH1A1 | |
| SCHEMBL1410824 | 0.77 | TAS1R3 (0.39) | TAS1R3TAS1R1METAP2KDM4EALDH1A1 | |
| SCHEMBL8195919 | 0.77 | HDAC3 (0.44) | ALDH1A1KMT2ASMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |