Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257402 | 0.86 | ALDH1A1 (0.39) | MAP2K1MAP2K2ALDH1A1CYP2C19 | |
| SCHEMBL13825680 | 0.77 | NPC1 (0.42) | MEN1KMT2AMAP2K1MAP2K2RAB9A | |
| SCHEMBL12810855 | 0.72 | NPC1 (0.42) | MEN1KMT2AMAP2K1MAP2K2RAB9A | |
| SCHEMBL7469020 | 0.71 | ALDH1A1 (0.46) | MAP2K1MAP2K2ALDH1A1CYP2C19 | |
| SCHEMBL14257536 | 0.70 | MAP2K1 (0.43) | MAP2K1MAP2K2ALDH1A1CYP2C19 | |
| SCHEMBL2650449 | 0.69 | HDAC1 (0.58) | MAP2K1MAP2K2RAB9AALDH1A1 | |
| SCHEMBL12810857 | 0.68 | NPC1 (0.41) | MEN1KMT2AMAP2K1MAP2K2RAB9A | |
| SCHEMBL31485290 | 0.67 | MAP2K1 (0.53) | MAP2K1MAP2K2RAB9AALDH1A1CYP2C19 | |
| SCHEMBL13825681 | 0.67 | MAP2K1 (0.43) | MEN1KMT2AMAP2K1MAP2K2RAB9A | |
| SCHEMBL12556990 | 0.67 | MAP2K1 (0.46) | MEN1KMT2AMAP2K1MAP2K2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298768-A1 | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer | Japan Tobacco, Inc. (JP) | 2011-03-23 | — | — | EP | disclosed |