Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442411 | 0.90 | GAA (0.52) | ATMPIK3CAGAAEPHX2GBA1 | |
| SCHEMBL10178945 | 0.88 | KDR (0.43) | ATMPIK3CAEPHX1KDM4EMEN1 | |
| SCHEMBL12811797 | 0.85 | CKS1B (0.50) | PIK3CAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1442447 | 0.84 | CYP1A2 (0.50) | PIK3CAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL1443207 | 0.82 | CXCR4 (0.49) | PIK3CAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1442311 | 0.80 | BMPR1B (0.47) | PIK3CAMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL12812416 | 0.80 | PIK3CA (0.47) | PIK3CAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1443006 | 0.80 | CKS1B (0.45) | ATMPIK3CA | |
| SCHEMBL12811787 | 0.78 | HTR2C (0.51) | KDM4EALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1442689 | 0.78 | SMN1; SMN2 (0.56) | KDM4EMEN1ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |