Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 4/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.44 |
| ▸ | NEK3 | P51956 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.44 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811797 | 0.93 | CKS1B (0.50) | CKS1BSKP1SKP2HPGDSSTK17A | |
| SCHEMBL12811789 | 0.92 | STK17A (0.49) | STK17ANEK3LIMK1NEK5MYLK4 | |
| SCHEMBL1443346 | 0.84 | MYLK4 (0.52) | STK17ANEK3LIMK1NEK5MYLK4 | |
| SCHEMBL1443590 | 0.84 | MAPK14 (0.50) | CKS1BSKP1SKP2HPGDSBMPR1B | |
| SCHEMBL12812434 | 0.84 | STK17A (0.51) | STK17ANEK3LIMK1NEK5MYLK4 | |
| SCHEMBL1442549 | 0.82 | PIK3CA (0.47) | PIK3CA | |
| SCHEMBL12812416 | 0.80 | PIK3CA (0.47) | CKS1BSKP1SKP2HPGDSTTK | |
| SCHEMBL1442311 | 0.80 | BMPR1B (0.47) | CKS1BSKP1SKP2HPGDSBMPR1B | |
| SCHEMBL12812066 | 0.80 | ATM (0.46) | ATMPIK3CA | |
| SCHEMBL1442107 | 0.79 | PIK3CA (0.47) | STK17AATMPRKDCPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473498-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2012-07-11 | — | — | EP | claimed |
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | claimed |