Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123175 | 0.83 | KDM4E (0.82) | KDM4EKMT2ANAMPTMLYCDPDE10A | |
| SCHEMBL7046909 | 0.81 | KMT2A (0.54) | KDM4EKMT2APDE10ANR1H4NPC1 | |
| Cyclopropane SCHEMBL28956243 | 0.79 | NR1H4 (0.47) | KDM4EKMT2ANAMPTTRPV1NR1H4 | |
| SCHEMBL95975 | 0.79 | KDM4E (0.65) | KDM4EKMT2ANAMPTMLYCDPDE10A | |
| SCHEMBL28816309 | 0.76 | LOXL2 (0.47) | KDM4EKMT2AMLYCDLOXL2HSD17B10 | |
| SCHEMBL3818379 | 0.76 | LOXL2 (0.55) | KDM4ENR1H4LOXL2HDAC3HDAC6 | |
| SCHEMBL10801846 | 0.75 | KDM4E (1.00) | KDM4EKMT2AMLYCDPDE10AHSD17B10 | |
| SCHEMBL15676811 | 0.75 | KMT2A (0.55) | KDM4EKMT2ANAMPTMLYCDPDE10A | |
| SCHEMBL14706958 | 0.75 | NAMPT (0.53) | KDM4EKMT2ANAMPTMLYCDPDE10A | |
| SCHEMBL16538470 | 0.74 | LOXL2 (0.58) | KMT2ALOXL2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023986-A1 | KINASE INHIBITORS | THE UNIVERSITY OF MANCHESTER (GB) | 2011-03-03 | — | — | WO | disclosed |