Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12812347 | 0.81 | HCRTR2 (0.41) | CALCRLTP53 | |
| SCHEMBL27812606 | 0.76 | HTR2C (0.39) | CALCRLPROKR1 | |
| SCHEMBL5553751 | 0.75 | CALCRL (0.41) | HPGDCALCRL | |
| SCHEMBL9233206 | 0.74 | HTR2C (0.43) | TP53 | |
| SCHEMBL29691690 | 0.74 | HTR2C (0.43) | TP53 | |
| SCHEMBL12812342 | 0.74 | HCRTR2 (0.42) | HPGDCALCRLTP53 | |
| SCHEMBL30663898 | 0.73 | RBP4 (0.47) | HPGDCALCRLKMT2AMEN1 | |
| SCHEMBL1822869 | 0.72 | CALCRL (0.40) | HPGDCALCRL | |
| SCHEMBL28247605 | 0.72 | HTR2C (0.44) | TP53 | |
| SCHEMBL12812353 | 0.70 | CALCRL (0.45) | LMNACALCRLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804919-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-03-30 | — | — | EP | disclosed |