Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813030 | 0.86 | PIK3CD (0.49) | PIK3CDPIK3C3PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12813247 | 0.81 | PIK3CD (0.38) | PIK3CDPIK3C3PIK3CGPIK3CAPIK3CB | |
| SCHEMBL9928787 | 0.78 | PIK3C3 (0.38) | PIK3CDPIK3C3PIK3CGPDE4DPIK3CA | |
| SCHEMBL9929002 | 0.72 | PIK3C3 (0.40) | PIK3CDPIK3C3PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12813032 | 0.67 | PIK3CD (0.48) | PIK3CDPIK3C3PIK3CGPIK3CAPIK3CB | |
| SCHEMBL22047639 | 0.67 | IMPDH2 (0.40) | MEN1MAPTHTTKMT2A | |
| SCHEMBL12813269 | 0.67 | PIK3CD (0.49) | PIK3CDPIK3C3PIK3CGPIK3CAPIK3CB | |
| SCHEMBL23074488 | 0.66 | ALDH1A1 (0.36) | MEN1MAPTHTTKMT2A | |
| SCHEMBL12813267 | 0.65 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL9929352 | 0.62 | HSP90AA1 (0.38) | MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135009-A1 | PYRIMIDINE-4,6-DIAMINE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-10-04 | — | — | WO | disclosed |