Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL4604674 | 0.86 | TLR2 (0.34) | TLR2DPP4 | |
| Glutamic Acid SCHEMBL16934712 | 0.82 | GRM8 (0.35) | — | |
| SCHEMBL3100834 | 0.81 | TLR2 (0.30) | TLR2 | |
| Asparagine SCHEMBL4995021 | 0.79 | NOS2 (0.32) | TLR2 | |
| Isoleucine SCHEMBL4400807 | 0.79 | DPP4 (0.37) | DPP4 | |
| Isoleucine SCHEMBL2496259 | 0.79 | DPP4 (0.37) | DPP4 | |
| Isoleucine SCHEMBL2498263 | 0.79 | DPP4 (0.37) | DPP4 | |
| Isoleucine SCHEMBL6163458 | 0.79 | DPP4 (0.37) | DPP4 | |
| Isoleucine SCHEMBL4406285 | 0.79 | DPP4 (0.37) | DPP4 | |
| Isoleucine SCHEMBL2492485 | 0.79 | DPP4 (0.37) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10064355-B2 | Rice cultivar designated ‘CL271’ | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2018-09-04 | — | — | US | disclosed |
| US-9480219-B2 | Rice cultivar designated ‘CL152’ | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2016-11-01 | — | — | US | disclosed |
| US-20160309673-A1 | Rice Cultivar Designated 'CL271' | Board of Supervisors of Louisiana State University and Agricultural and amechanical College (US) | 2016-10-27 | — | — | US | disclosed |
| WO-2015088933-A1 | RICE CULTIVAR DESIGNATED 'CL271' | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20140230086-A1 | Rice Cultivar Designated 'CL152' | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-08-14 | — | — | US | disclosed |
| EP-2690946-A1 | RICE CULTIVAR DESIGNATED 'CL152' | Board of Supervisors of Lousiana State University (US) | 2014-02-05 | — | — | EP | disclosed |
| WO-2012135558-A1 | RICE CULTIVAR DESIGNATED 'CL152' | Board of Supervisor of Louisiana State University and Agricultural and Mechanical College (US) | 2012-10-04 | — | — | WO | disclosed |