Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817923 | 0.92 | LMNA (0.47) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818050 | 0.91 | PKM (0.43) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818150 | 0.90 | PKM (0.44) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818981 | 0.89 | CYP11B1 (0.47) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818716 | 0.88 | PKM (0.43) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818524 | 0.88 | PKM (0.44) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818462 | 0.88 | PKM (0.46) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818561 | 0.87 | PKM (0.43) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818068 | 0.86 | PKM (0.43) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12817702 | 0.86 | PKM (0.41) | PKMPKLRKDM2BLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |