Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 4/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818351 | 0.85 | PIK3CA (0.39) | PGRMEN1KMT2ACYP2C9MAPT | |
| SCHEMBL12818115 | 0.85 | NPC1 (0.42) | PGRMEN1KMT2ACYP2C9ALDH1A1 | |
| SCHEMBL12818426 | 0.84 | PGR (0.59) | PGRMEN1KMT2ACYP2C9ALDH1A1 | |
| SCHEMBL1818909 | 0.84 | PKM (0.48) | MEN1KMT2ACYP2C9ALDH1A1PKM | |
| SCHEMBL12818531 | 0.84 | PKM (0.45) | PGRMEN1KMT2ACYP2C9PDE3B | |
| SCHEMBL12817667 | 0.83 | PGR (0.39) | PGRMEN1KMT2ACYP2C9MAPT | |
| SCHEMBL1818674 | 0.82 | CYP2C9 (0.53) | PGRMEN1KMT2ACYP2C9MAPT | |
| SCHEMBL1820314 | 0.81 | MEN1 (0.42) | PGRMEN1KMT2ACYP2C9MAPT | |
| SCHEMBL1819540 | 0.81 | PKM (0.41) | PGRMEN1KMT2ACYP2C9MAPT | |
| SCHEMBL12818990 | 0.81 | CYP2C9 (0.38) | PGRMEN1KMT2ACYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |