Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20578257 | 0.87 | PIK3C2B (0.43) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL1281782 | 0.84 | MAPT (0.47) | ALDH1A1KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL1281793 | 0.84 | NPC1 (0.42) | ALDH1A1KDM4EMAPTMEN1NPC1 | |
| SCHEMBL1688037 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL1282463 | 0.84 | MAPT (0.43) | ALDH1A1KDM4EMAPTMEN1NPC1 | |
| SCHEMBL1281993 | 0.74 | PDE3B (0.44) | ALDH1A1MAPTMEN1NPC1RAB9A | |
| SCHEMBL27903995 | 0.74 | KDM4E (0.35) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL1632059 | 0.73 | PRKDC (0.44) | ALDH1A1KDM4EMAPTALOX15PIK3CB | |
| SCHEMBL1632944 | 0.72 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTMEN1NPC1 | |
| SCHEMBL27921643 | 0.72 | KDM4E (0.51) | KDM4ESMN1; SMN2PIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170813-B1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-12-12 | — | — | EP | claimed |
| EP-3170813-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-24 | — | — | EP | claimed |
| US-8435988-B2 | Benzimidazole derivatives as P13 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-05-07 | — | — | US | claimed |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-04-12 | — | — | US | claimed |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190255064-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2019-08-22 | — | — | US | disclosed |
| US-10314845-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2019-06-11 | — | — | US | disclosed |
| EP-3170813-B1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-12-12 | — | — | EP | disclosed |
| US-20180263994-A1 | Benzimidazole Derivatives as PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2018-09-20 | — | — | US | disclosed |
| US-9872860-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2018-01-23 | — | — | US | disclosed |
| EP-3170813-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-24 | — | — | EP | disclosed |
| US-20170112844-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2017-04-27 | — | — | US | disclosed |
| US-20140018534-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-01-16 | — | — | US | disclosed |
| US-8541411-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-09-24 | — | — | US | disclosed |
| EP-2624696-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-08-14 | — | — | EP | disclosed |
| US-20130196990-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2013-08-01 | — | — | US | disclosed |
| US-20130197221-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-08-01 | — | — | US | disclosed |
| US-8435988-B2 | Benzimidazole derivatives as P13 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-04-12 | — | — | US | disclosed |
| WO-2012047538-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112844-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
| US-20180263994-A1 | Benzimidazole Derivatives as PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
| US-20140018534-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1428/4885KDM4E 2943/4885LMNA 4759/4885 |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KB, PI4KA, PIK3CD | ALDH1A1 1291/4885KDM4E 2861/4885LMNA 4764/4885 |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
| US-20130196990-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
| US-10314845-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
| US-20130197221-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
| US-20190255064-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885KDM4E 2969/4885LMNA 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.