Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27921643 | 0.89 | KDM4E (0.51) | PIK3C2BKDM4EHPGDPIK3CDPIK3R1 | |
| SCHEMBL1688037 | 0.88 | ALDH1A1 (0.44) | PIK3C2BMAPTKDM4EHPGDPIK3CD | |
| SCHEMBL20578257 | 0.74 | PIK3C2B (0.43) | PIK3C2BMAPTKDM4EPIK3CDPIK3R1 | |
| SCHEMBL1282185 | 0.73 | ALDH1A1 (0.43) | MAPTKDM4EPIK3CDPIK3CBALDH1A1 | |
| SCHEMBL28805891 | 0.73 | GNRHR (0.37) | PIK3C2BMAPTKDM4EHPGDPIK3CD | |
| SCHEMBL27903775 | 0.73 | DHODH (0.54) | PIK3C2BPIK3CDPIK3R1PIK3CB | |
| SCHEMBL27903777 | 0.72 | PIK3R2 (0.40) | PRKDCPIK3C2BPIK3CDPIK3R1PIK3CB | |
| SCHEMBL27921732 | 0.71 | PIK3C2B (0.46) | PIK3C2BMAPTKDM4EPIK3CDPIK3R1 | |
| SCHEMBL1632944 | 0.71 | ALDH1A1 (0.47) | MAPTKDM4EPIK3CDPIK3CBALDH1A1 | |
| SCHEMBL1633300 | 0.70 | PIK3CB (0.45) | PIK3C2BMAPTKDM4EPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9872860-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170112844-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2017-04-27 | — | — | US | disclosed |
| US-9156797-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-10-13 | — | — | US | disclosed |
| US-20150246889-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2015-09-03 | — | — | US | disclosed |
| US-9062003-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140378456-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2014-12-25 | — | — | US | disclosed |
| US-8865912-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-10-21 | — | — | US | disclosed |
| US-20140142321-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-05-22 | — | — | US | disclosed |
| US-8674090-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-03-18 | — | — | US | disclosed |
| US-20140018534-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-01-16 | — | — | US | disclosed |
| US-8541411-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-09-24 | — | — | US | disclosed |
| US-20130196990-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2013-08-01 | — | — | US | disclosed |
| US-20130197221-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-08-01 | — | — | US | disclosed |
| US-8435988-B2 | Benzimidazole derivatives as P13 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112844-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 92/4885PIK3C2B 13/4885MAPT 3380/4885 |
| US-20140018534-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 91/4885PIK3C2B 13/4885MAPT 3347/4885 |
| US-20140378456-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 92/4885PIK3C2B 13/4885MAPT 3380/4885 |
| US-20140142321-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 92/4885PIK3C2B 13/4885MAPT 3380/4885 |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KB, PI4KA, PIK3CD | PRKDC 103/4885PIK3C2B 13/4885MAPT 3376/4885 |
| US-20130196990-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 92/4885PIK3C2B 13/4885MAPT 3380/4885 |
| US-20150246889-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 92/4885PIK3C2B 13/4885MAPT 3380/4885 |
| US-20130197221-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | PRKDC 92/4885PIK3C2B 13/4885MAPT 3380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.