SCHEMBL12824331

SCHEMBL12824331

COC(=O)c1ccc2c(c1)nc(-c1ccc(Cl)cc1)c1ccncc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 16/20 1.00
CSNK2B P67870 16/20 1.00
CSNK2A1 P68400 6/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1450213 0.89 CSNK2A2 (0.80) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12743893 0.87 CSNK2A2 (0.80) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12743673 0.86 CSNK2A2 (1.00) CSNK2A2CSNK2BCSNK2A1
SCHEMBL629013 0.83 CSNK2A2 (0.71) CSNK2A2CSNK2BCSNK2A1
SCHEMBL20704178 0.82 HIPK2 (0.71) CSNK2A2CSNK2BCSNK2A1
SCHEMBL1451933 0.82 CSNK2A2 (0.69) CSNK2A2CSNK2BCSNK2A1
SCHEMBL2690184 0.81 CSNK2A2 (0.68) CSNK2A2CSNK2BCSNK2A1
SCHEMBL8890757 0.80 CSNK2A1 (0.66) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12743705 0.78 CSNK2A2 (0.78) CSNK2A2CSNK2BCSNK2A1
SCHEMBL20149547 0.78 CDH1 (0.69) CSNK2A2CSNK2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7910600-B2 Therapeutic kinase modulators CYLENE PHARMACEUTICALS, INC. (US) 2011-03-22 US disclosed