Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10292615 | 0.84 | SMO (0.35) | HTTMEN1KMT2AUGCGMAPT | |
| SCHEMBL12824596 | 0.79 | SMO (0.37) | HTTUGCGKDM4EALDH1A1LMNA | |
| SCHEMBL12824856 | 0.79 | SMO (0.37) | HTTMEN1KMT2AUGCGALDH1A1 | |
| SCHEMBL10003404 | 0.73 | HTT (0.40) | HTTMEN1KMT2AUGCGMAPT | |
| SCHEMBL12825027 | 0.70 | SMO (0.43) | HTTMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10003336 | 0.69 | SMN1; SMN2 (0.41) | HTTMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL12825060 | 0.69 | SMO (0.43) | MEN1KMT2AMAPTALDH1A1TP53 | |
| SCHEMBL10003606 | 0.68 | ITK (0.39) | MEN1KMT2ASMN1; SMN2RAB9AGSK3B | |
| SCHEMBL12824727 | 0.68 | SMO (0.45) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12825025 | 0.68 | SMO (0.48) | NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011024869-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2011-03-03 | — | — | WO | disclosed |