Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.63 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826573 | 0.92 | AURKA (0.70) | LRRK2AURKAAURKBBRD4IGF1R | |
| SCHEMBL12826568 | 0.91 | AURKA (0.59) | LRRK2INSRALKAURKAAURKB | |
| SCHEMBL12826705 | 0.90 | LRRK2 (0.64) | LRRK2AURKAAURKBBRD4IGF1R | |
| SCHEMBL12826565 | 0.89 | LRRK2 (0.66) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826690 | 0.89 | LRRK2 (0.66) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826703 | 0.88 | LRRK2 (0.67) | LRRK2INSRALKAURKAAURKB | |
| SCHEMBL16995435 | 0.88 | PTK2 (0.68) | LRRK2ALKAURKAAURKBBRD4 | |
| SCHEMBL12826702 | 0.87 | LRRK2 (0.62) | LRRK2AURKAAURKBBRD4PTK2 | |
| SCHEMBL12826701 | 0.87 | LRRK2 (0.60) | LRRK2INSRALKPTK2 | |
| SCHEMBL12826742 | 0.86 | LRRK2 (0.65) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |
| US-20140051674-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-20 | — | — | US | disclosed |
| US-20110071158-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-24 | — | — | US | disclosed |
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051674-A1 | NEW COMPOUNDS | CCNA1, MKI67, CCNT1 | LRRK2 1540/4885INSR 6/4885ALK 2070/4885 |
| US-20110071158-A1 | NEW COMPOUNDS | CCNA1, MKI67, CCNT1 | LRRK2 1540/4885INSR 6/4885ALK 2070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.