Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.56 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 4/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.52 |
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.51 |
| ▸ | TAF1 | P21675 | 2/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | FES | P07332 | 2/20 | 0.50 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | NEK2 | P51955 | 2/20 | 0.50 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826566 | 0.92 | AURKA (0.70) | AURKAAURKBLRRK2IGF1RPLK1 | |
| SCHEMBL12826445 | 0.91 | LRRK2 (0.63) | AURKAAURKBLRRK2IGF1RPLK1 | |
| SCHEMBL12826572 | 0.90 | LRRK2 (0.59) | AURKAAURKBLRRK2IGF1RPLK1 | |
| SCHEMBL12826565 | 0.89 | LRRK2 (0.66) | AURKAAURKBLRRK2PTK2 | |
| SCHEMBL12826690 | 0.89 | LRRK2 (0.66) | AURKAAURKBLRRK2PTK2 | |
| SCHEMBL16995449 | 0.88 | PTK2 (0.57) | AURKAAURKBLRRK2PLK1PLK3 | |
| SCHEMBL12826856 | 0.88 | AURKA (0.56) | AURKAAURKBLRRK2BRD4PTK2 | |
| SCHEMBL12826440 | 0.87 | AURKA (0.59) | AURKAAURKBLRRK2PLK1BRD4 | |
| SCHEMBL12826862 | 0.87 | LRRK2 (0.56) | AURKAAURKBLRRK2PLK1PLK3 | |
| SCHEMBL12826947 | 0.86 | LRRK2 (0.56) | AURKAAURKBLRRK2CLK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |
| US-20140051674-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-20 | — | — | US | disclosed |
| US-20110071158-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-24 | — | — | US | disclosed |
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051674-A1 | NEW COMPOUNDS | CCNA1, MKI67, CCNT1 | AURKA 2693/4885AURKB 1255/4885LRRK2 1540/4885 |
| US-20110071158-A1 | NEW COMPOUNDS | CCNA1, MKI67, CCNT1 | AURKA 2693/4885AURKB 1255/4885LRRK2 1540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.