Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 9/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.55 |
| ▸ | PLK1 | P53350 | 3/20 | 0.55 |
| ▸ | BRD4 | O60885 | 3/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.55 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.48 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16995435 | 0.91 | PTK2 (0.68) | PTK2AURKAAURKBLRRK2PLK1 | |
| SCHEMBL12826856 | 0.91 | AURKA (0.56) | PTK2AURKAAURKBLRRK2BRD4 | |
| SCHEMBL12826566 | 0.90 | AURKA (0.70) | PTK2AURKAAURKBLRRK2PLK1 | |
| SCHEMBL12826947 | 0.89 | LRRK2 (0.56) | AURKAAURKBLRRK2 | |
| SCHEMBL12826572 | 0.89 | LRRK2 (0.59) | PTK2AURKAAURKBLRRK2PLK1 | |
| SCHEMBL12826568 | 0.88 | AURKA (0.59) | PTK2AURKAAURKBLRRK2PLK1 | |
| SCHEMBL12826440 | 0.87 | AURKA (0.59) | PTK2AURKAAURKBLRRK2PLK1 | |
| SCHEMBL12826700 | 0.87 | LRRK2 (0.57) | AURKAAURKBLRRK2 | |
| SCHEMBL12826862 | 0.86 | LRRK2 (0.56) | AURKAAURKBLRRK2PLK1PLK3 | |
| SCHEMBL12826857 | 0.85 | PLK1 (0.55) | PTK2AURKAAURKBLRRK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |