Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12828765 | 0.70 | PARP1 (0.38) | PARP1 | |
| SCHEMBL5138055 | 0.67 | PARP1 (0.43) | PARP1 | |
| SCHEMBL12828304 | 0.62 | PARP3 (0.42) | PARP1 | |
| SCHEMBL12828175 | 0.62 | PARP3 (0.45) | PARP1 | |
| SCHEMBL168935 | 0.62 | PDGFRA (0.52) | PBRM1PDE7APDE7B | |
| SCHEMBL25138054 | 0.61 | PARP1 (0.41) | PARP1SMARCA2SMARCA4PBRM1 | |
| SCHEMBL9790400 | 0.61 | MAPT (0.39) | PARP1 | |
| SCHEMBL4491151 | 0.61 | — | — | |
| SCHEMBL14494611 | 0.61 | CCKBR (0.40) | PARP1 | |
| SCHEMBL14085127 | 0.60 | PARP1 (0.33) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915280-B2 | Compounds and their uses | EISAI INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-RE41150-E1 | Poly(adenosine 5'-diphospho-ribose) polymerase (PARP) inhibitors; compounds based on thieno(4,3,2-ef)(2)benzazepin-6-one | EISAI CORPORATION OF NORTH AMERICA (US) | 2010-02-23 | — | — | US | disclosed |