Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549331 | 0.78 | KDM1A (0.50) | KDM1AMEN1KMT2ACASP6AKR1B1 | |
| SCHEMBL5547924 | 0.76 | KDM1A (0.53) | KDM1AMEN1KMT2ACASP6AKR1B1 | |
| SCHEMBL4453771 | 0.75 | KDM1A (0.47) | KDM1AMEN1KMT2ACASP6AKR1B1 | |
| Hydrogen Peroxide SCHEMBL1204658 | 0.75 | KDM1A (0.47) | KDM1AMEN1KMT2ACASP6AKR1B1 | |
| SCHEMBL5547881 | 0.72 | KDM1A (0.49) | KDM1AMEN1KMT2ACASP6AKR1B1 | |
| SCHEMBL578812 | 0.71 | KDM1A (0.59) | KDM1AMEN1KMT2AAKR1B1SIGMAR1 | |
| SCHEMBL29556050 | 0.71 | KDM1A (0.59) | KDM1AMEN1KMT2AAKR1B1SIGMAR1 | |
| SCHEMBL5547915 | 0.70 | SIGMAR1 (0.45) | KDM1AMEN1KMT2ACASP6SIGMAR1 | |
| SCHEMBL7782439 | 0.69 | KDM1A (0.44) | KDM1ASIGMAR1TP53TSHRHTR2A | |
| SCHEMBL11079677 | 0.69 | KDM1A (0.49) | KDM1AMEN1KMT2ACASP6AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077233-A1 | C-Met Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077233-A1 | C-Met Modulators and Method of Use | FLT4, MET, FLT1 | KDM1A 935/4885MEN1 1333/4885KMT2A 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.