Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.62 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.62 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 6/20 | 0.52 |
| ▸ | MMP2 | P08253 | 6/20 | 0.52 |
| ▸ | MMP9 | P14780 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 8/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830153 | 0.92 | TRPA1 (0.56) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12830151 | 0.92 | TRPA1 (0.56) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12830156 | 0.80 | TRPM2 (0.48) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12830158 | 0.80 | GAA (0.49) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12830155 | 0.79 | TRPA1 (0.56) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12829852 | 0.77 | TRPA1 (0.54) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12830154 | 0.77 | TRPA1 (0.43) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12830152 | 0.77 | TRPA1 (0.43) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12319232 | 0.76 | KMT2A (1.00) | MAPTSMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL12756723 | 0.75 | MEN1 (0.59) | MAPTSMN1; SMN2KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2014-02-20 | — | — | US | disclosed |
| WO-2011034962-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-03-24 | — | — | WO | disclosed |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | MAPT 1478/4885SMN1; SMN2 854/4885KMT2A 4706/4885 |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | MAPT 1478/4885SMN1; SMN2 854/4885KMT2A 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.