Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.77 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830487 | 0.92 | GRM5 (0.65) | GRM5CSF1RL3MBTL1BRAFALDH1A1 | |
| SCHEMBL6926675 | 0.89 | GRM5 (0.76) | GRM5 | |
| SCHEMBL12416470 | 0.88 | GRM5 (0.78) | GRM5CSF1RL3MBTL1BRAFMAPT | |
| SCHEMBL12830299 | 0.87 | GRM5 (0.59) | GRM5CSF1RL3MBTL1BRAFALDH1A1 | |
| SCHEMBL6926583 | 0.87 | GRM5 (1.00) | GRM5CSF1RL3MBTL1BRAFMAPT | |
| SCHEMBL6926593 | 0.86 | GRM5 (0.63) | GRM5CSF1RL3MBTL1BRAFALDH1A1 | |
| SCHEMBL12416474 | 0.84 | GRM5 (0.81) | GRM5CSF1RL3MBTL1BRAFALDH1A1 | |
| SCHEMBL12416823 | 0.84 | GRM5 (1.00) | GRM5CSF1RBRAFALDH1A1 | |
| SCHEMBL12830293 | 0.83 | GRM5 (0.53) | GRM5CSF1R | |
| SCHEMBL12830501 | 0.82 | GRM5 (0.62) | GRM5CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035174-A1 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |