Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 12/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.49 |
| ▸ | NPC1 | O15118 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10022340 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL20023741 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL12758858 | 0.80 | TP53 (0.33) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL1426320 | 0.79 | KDM4E (0.39) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL20985962 | 0.79 | TLR9 (0.46) | SMN1; SMN2TP53RAB9ANPC1CYP1A2 | |
| SCHEMBL26611347 | 0.76 | KDM4E (0.56) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL434154 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL6544490 | 0.74 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL18569907 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53RAB9AKDM4ENPC1 | |
| SCHEMBL8811617 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53RAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071129-A1 | SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE | MSD K.K. (JP) | 2011-03-24 | — | — | US | disclosed |
| WO-2010147234-A1 | DIARYLAMIDE-SPIRODIAMINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071129-A1 | SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE | MCHR2, MCHR1, ADRB2 | SMN1; SMN2 2582/4885TP53 4820/4885RAB9A 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.