Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834296 | 0.87 | F10 (0.37) | F10RAB9ANPC1LRRK2IKBKB | |
| SCHEMBL14089982 | 0.76 | MAPT (0.42) | F10RAB9ANPC1LRRK2IKBKB | |
| SCHEMBL14089979 | 0.70 | KDM4E (0.41) | F10RAB9ANPC1LRRK2IKBKB | |
| SCHEMBL12834312 | 0.66 | ABCB1 (0.32) | — | |
| SCHEMBL12834303 | 0.64 | POLB (0.38) | F10RAB9ANPC1MAPTKMT2A | |
| SCHEMBL31254445 | 0.59 | HSD17B10 (0.60) | F10RAB9ANPC1MAPTKMT2A | |
| SCHEMBL31254451 | 0.57 | RAB9A (1.00) | F10RAB9ANPC1MAPTKMT2A | |
| SCHEMBL31254420 | 0.56 | HSD17B10 (0.63) | RAB9ANPC1MAPTKMT2AALDH1A1 | |
| SCHEMBL5401508 | 0.55 | F10 (0.81) | F10RAB9ANPC1MAPTKMT2A | |
| SCHEMBL5409547 | 0.55 | F10 (0.81) | F10RAB9ANPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |