Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.81 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409547 | 0.94 | F10 (0.81) | F10RAB9ANPC1KLKB1ALDH1A1 | |
| SCHEMBL9976456 | 0.90 | F10 (0.72) | F10RAB9ANPC1MAPTKMT2A | |
| SCHEMBL5403144 | 0.84 | F10 (1.00) | F10RAB9ANPC1KLKB1 | |
| SCHEMBL5398111 | 0.84 | F10 (1.00) | F10RAB9ANPC1KLKB1 | |
| SCHEMBL31254451 | 0.84 | RAB9A (1.00) | F10RAB9ANPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5441402 | 0.84 | F10 (1.00) | F10RAB9ANPC1KLKB1 | |
| SCHEMBL9976457 | 0.83 | F10 (0.70) | F10RAB9ANPC1ALDH1A1MAPT | |
| Darexaban SCHEMBL2227024 | 0.80 | F10 (1.00) | F10KLKB1 | |
| SCHEMBL2230035 | 0.80 | F10 (1.00) | F10KLKB1 | |
| SCHEMBL13856556 | 0.79 | MAPT (1.00) | F10RAB9ANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43481-E1 | Diazepan derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2012-06-19 | — | — | US | claimed |
| US-7307074-B2 | Activated blood coagulation factor X inhibitor and also to such a pharmaceutical agent and particularly has an excellent activity by oral administration | ASTELLAS PHARMA INC. (JP) | 2007-12-11 | — | — | US | claimed |
| US-RE43481-E1 | Diazepan derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-7307074-B2 | Activated blood coagulation factor X inhibitor and also to such a pharmaceutical agent and particularly has an excellent activity by oral administration | ASTELLAS PHARMA INC. (JP) | 2007-12-11 | — | — | US | disclosed |
| US-7307074-B2 | Activated blood coagulation factor X inhibitor and also to such a pharmaceutical agent and particularly has an excellent activity by oral administration | ASTELLAS PHARMA INC. (JP) | 2007-12-11 | — | — | US | disclosed |