Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12243125 | 1.00 | HRH4 (0.33) | HRH4HRH3PDE4DLMNA | |
| SCHEMBL12243148 | 0.89 | TNK2 (0.34) | HRH4HRH3PDE4DLMNA | |
| SCHEMBL23823026 | 0.89 | TNK2 (0.34) | HRH4HRH3PDE4DLMNA | |
| SCHEMBL12835932 | 0.85 | BACE1 (0.32) | HRH4HRH3 | |
| SCHEMBL13667662 | 0.84 | PTPN1 (0.37) | — | |
| SCHEMBL10120783 | 0.81 | TNK2 (0.36) | — | |
| SCHEMBL12836635 | 0.81 | HRH4 (0.34) | HRH4HRH3LMNA | |
| SCHEMBL23278048 | 0.80 | TNK2 (0.33) | HRH4HRH3PDE4DLMNA | |
| SCHEMBL22579701 | 0.79 | HRH4 (0.31) | HRH4HRH3 | |
| SCHEMBL12243226 | 0.79 | NPC1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035250-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-03-24 | — | — | WO | disclosed |