Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | RAB9A | P51151 | 2/20 | 0.79 |
| ▸ | MAOA | P21397 | 3/20 | 0.64 |
| ▸ | MAOB | P27338 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301210 | 0.89 | HPGD (1.00) | HPGDMAPTRAB9AMAOBSMN1; SMN2 | |
| SCHEMBL203697 | 0.89 | HPGD (1.00) | HPGDMAPTRAB9AMAOBSMN1; SMN2 | |
| SCHEMBL75640 | 0.87 | MAPT (0.69) | HPGDMAPTRAB9AMAOAMAOB | |
| SCHEMBL28193245 | 0.87 | MAPT (0.69) | HPGDMAPTRAB9AMAOAMAOB | |
| SCHEMBL17187946 | 0.87 | MAPT (0.69) | HPGDMAPTRAB9AMAOAMAOB | |
| SCHEMBL13252903 | 0.85 | HPGD (0.58) | HPGDMAPTRAB9AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL27858043 | 0.84 | MAPT (0.67) | HPGDMAPTRAB9AMAOAMAOB | |
| Ammonia Solution, Strong SCHEMBL17180520 | 0.84 | MAPT (0.67) | HPGDMAPTRAB9AMAOAMAOB | |
| SCHEMBL20836631 | 0.83 | HPGD (0.79) | HPGDMAPTRAB9AMAOAMAOB | |
| SCHEMBL9789228 | 0.83 | MAPT (0.86) | HPGDMAPTRAB9AMAOBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112409142-B | Preparation method of 4-p-chlorophenoxyl acetophenone compounds | 帕潘纳(北京)科技有限公司 | 2022-04-19 | — | — | CN | claimed |
| CN-112409142-A | Preparation method of 4-p-chlorophenoxyl acetophenone compounds | 帕潘纳(北京)科技有限公司 | 2021-02-26 | — | — | CN | claimed |
| EP-0986540-B1 | THE USE OF CARBOCYCLIC AND HETEROCYCLIC SUBSTITUTED SEMICARBAZONES AND THIOSEMICARBAZONES AS SODIUM CHANNEL BLOCKERS | EURO CELTIQUE SA (LU) | 2005-02-16 | — | — | EP | claimed |
| US-6696442-B2 | THERAPY OF DISORDER RESPONSIVE TO THE BLOCKADE OF SODIUM CHANNELS IN A MAMMAL SUFFERING THEREFROM BY ADMINISTERING CARBOCYCLIC AND HETEROCYCLIC SUBSTITUTED SEMICARBAZONES AND THIOSEMICARBAZONES, WHICH ACT AS BLOCKERS OF SODIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2004-02-24 | — | — | US | claimed |
| US-20030225080-A1 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof | EURO-CELTIQUES S.A. | 2003-12-04 | — | — | US | claimed |
| US-6613803-B1 | Treating, preventing or ameliorating pain | EURO-CELTIQUE S.A. (LU) | 2003-09-02 | — | — | US | claimed |
| US-20020183321-A1 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof | COCENSYS, INC. | 2002-12-05 | — | — | US | claimed |
| US-20020061886-A1 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof | COCENSYS, INC. | 2002-05-23 | — | — | US | claimed |
| CN-113666819-B | Method for preparing penconazole intermediate | 帕潘纳(北京)科技有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-114456048-B | Preparation method of penconazole intermediate | 帕潘纳(北京)科技有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-114539041-B | Preparation method of penconazole intermediate | 帕潘纳(北京)科技有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-116018138-A | Substituted 1H-imidazo [1,2-b ] pyrazole-3-carboxamides as inhibitors of brunauer tyrosine kinase | 河南知微生物医药有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-114539041-A | Preparation method of chlorofluoroether ipconazole intermediate | 帕潘纳(北京)科技有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-114456048-A | Preparation method of chlorofluoromethane intermediate | 帕潘纳(北京)科技有限公司 | 2022-05-10 | — | — | CN | disclosed |
| EP-0065485-A2 | Arylphenyl ether derivatives as microbicides, process for their preparation and their application | CIBA-GEIGY AG (CH) | 1982-11-24 | — | — | EP | disclosed |
| US-4287213-A | Dichloroacyl diphenyl ether mite ovacides | CHEVRON RESEARCH COMPANY (US) | 1981-09-01 | — | — | US | disclosed |
| US-4196215-A | Alkyne compounds and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1980-04-01 | — | — | US | disclosed |
| US-4136200-A | PHENYLBUTANOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-01-23 | — | — | US | disclosed |
| US-4115456-A | Alkyne compounds and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1978-09-19 | — | — | US | disclosed |
| US-4049823-A | Phenylbutanol derivatives and compositions containing them | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225080-A1 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof | GLRB, SLC1A1, SOD1 | HPGD 1599/4885MAPT 2250/4885RAB9A 4389/4885 |
| US-20020061886-A1 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof | GLRB, SLC1A1, SOD1 | HPGD 1599/4885MAPT 2250/4885RAB9A 4389/4885 |
| US-20020183321-A1 | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof | GLRB, CBR1, ALDH1A2 | HPGD 1752/4885MAPT 2452/4885RAB9A 4404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.