Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.54 |
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | TACR2 | P21452 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SHBG | P04278 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31331684 | 0.98 | HSD17B3 (0.56) | HSD17B3DGKAESR1ADRA2AADORA3 | |
| SCHEMBL125475 | 0.98 | HSD17B3 (0.56) | HSD17B3DGKAESR1ADRA2AADORA3 | |
| SCHEMBL3814877 | 0.93 | DGKA (0.60) | DGKALMNAKDM4EALDH1A1ELANE | |
| SCHEMBL5709846 | 0.88 | ALDH1A1 (0.51) | DGKALMNAKDM4EALDH1A1ELANE | |
| SCHEMBL4206910 | 0.88 | DGKA (0.55) | DGKALMNAKDM4EALDH1A1ELANE | |
| SCHEMBL4207553 | 0.88 | DGKA (0.55) | DGKALMNAKDM4EALDH1A1ELANE | |
| SCHEMBL18087035 | 0.88 | DGKA (0.55) | DGKALMNAALDH1A1ELANEMEN1 | |
| SCHEMBL4219075 | 0.88 | DGKA (0.55) | DGKALMNAKDM4EALDH1A1ELANE | |
| SCHEMBL4212801 | 0.88 | DGKA (0.55) | DGKALMNAKDM4EALDH1A1ELANE | |
| SCHEMBL4211547 | 0.88 | DGKA (0.55) | DGKALMNAKDM4EALDH1A1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108770357-A | Polymer combined vaccine | 芝加哥大学 | 2018-11-06 | — | — | CN | disclosed |
| EP-2428577-B1 | Preparation of tyrosinase-inhibiting hydroxybenzyl and hydroxypyranonemethyl esters | EASTMAN CHEM CO (US) | 2014-01-22 | — | — | EP | disclosed |
| EP-2428577-A1 | Preparation of tyrosinase-inhibiting hydroxybenzyl and hydroxypyranonemethyl esters | EASTMAN CHEMICAL COMPANY (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2155886-B1 | Cosmetic use of inhibitors of tyrosinase | EASTMAN CHEM CO (US) | 2012-03-07 | — | — | EP | disclosed |
| US-20110129430-A1 | HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS | EASTMAN CHEMICAL COMPANY (US) | 2011-06-02 | — | — | US | disclosed |
| EP-2155886-A2 | HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS | Eastman Chemical Company (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008153784-A2 | HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS | EASTMAN CHEMICAL COMPANY (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129430-A1 | HYDROXYBENZYL OR HYDROXYPYRANONEMETHYL ESTERS AS TYROSINASE INHIBITORS | TYR, TH, HAAO | HSD17B3 50/4885DGKA 710/4885ESR1 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.