Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 11/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | MELK | Q14680 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064437 | 0.81 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL21237108 | 0.81 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12727794 | 0.81 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12765395 | 0.81 | CSF1R (0.53) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL11926760 | 0.78 | TLK2 (0.63) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL6394041 | 0.74 | TLK2 (0.65) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL6394046 | 0.74 | TLK2 (0.65) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL8351341 | 0.74 | RAF1 (0.55) | MAPTCDK2MAPK1NTRK1PLK4 | |
| SCHEMBL8351339 | 0.74 | RAF1 (0.55) | MAPTCDK2MAPK1NTRK1PLK4 | |
| SCHEMBL20401696 | 0.71 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897619-B2 | Heterocyclic modulators of PKB | AMGEN INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090275592-A1 | Heterocyclic modulators of PKB | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275592-A1 | Heterocyclic modulators of PKB | MTOR, PDK1, EIF4EBP1 | TLK2 1062/4885CDK5 162/4885MAPT 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.