Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 8/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.63 |
| ▸ | CSF1R | P07333 | 7/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CDK9 | P50750 | 2/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12727794 | 0.90 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12064437 | 0.90 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12722125 | 0.84 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL20402601 | 0.81 | TLK2 (0.63) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL20402600 | 0.81 | CSF1R (0.72) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12123831 | 0.80 | PDPK1 (0.67) | TLK2CDK5CSF1RRETKDR | |
| SCHEMBL20401696 | 0.78 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12838026 | 0.78 | TLK2 (0.51) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL29476105 | 0.78 | TLK2 (1.00) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL7828051 | 0.77 | TLK2 (0.72) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208819-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208819-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | TLK2 719/4885CDK5 269/4885MAPT 3529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.