SCHEMBL12839155

SCHEMBL12839155

CCc1nc(-c2ccc(F)cc2)cnc1NC(=O)CCCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 2/20 0.46
MAPK14 Q16539 1/20 0.46
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
FAAH O00519 1/20 0.41
MAPK1 P28482 1/20 0.41
ATR Q13535 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
HDAC1 Q13547 1/20 0.41
MMP2 P08253 1/20 0.41
MMP13 P45452 1/20 0.41
TRPV1 Q8NER1 1/20 0.40
KDM6B O15054 1/20 0.40
KDM4D Q6B0I6 1/20 0.40
KDM4C Q9H3R0 1/20 0.40
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839162 0.94 HCAR2 (0.47) LMNASMN1; SMN2NPC1RAB9AMAPK14
SCHEMBL12840043 0.93 LMNA (0.46) LMNASMN1; SMN2NPC1RAB9AMAPK14
SCHEMBL12840352 0.93 NPC1 (0.50) SMN1; SMN2NPC1RAB9AALDH1A1GAA
SCHEMBL12840018 0.92 LMNA (0.48) LMNASMN1; SMN2NPC1RAB9AMAPK14
SCHEMBL12838908 0.91 TRPV1 (0.52) SMN1; SMN2NPC1RAB9AALDH1A1GAA
SCHEMBL12839075 0.91 LMNA (0.47) LMNASMN1; SMN2NPC1RAB9AMAPK14
SCHEMBL12840499 0.90 NPC1 (0.46) SMN1; SMN2NPC1RAB9AALDH1A1GAA
SCHEMBL12840035 0.89 LMNA (0.44) LMNASMN1; SMN2NPC1RAB9AMAPK14
SCHEMBL12839167 0.87 MAPK14 (0.48) LMNANPC1RAB9AMAPK14ALDH1A1
SCHEMBL12840351 0.86 MAPT (0.47) LMNASMN1; SMN2NPC1RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 LMNA 3662/4885SMN1; SMN2 4784/4885NPC1 2936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.