SCHEMBL12840474

SCHEMBL12840474

CCCc1nc(-c2ccc(F)cc2)cnc1NC(=O)Cc1ccc(Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.46
TP53 P04637 1/20 0.46
THRB P10828 1/20 0.46
MAPT P10636 1/20 0.45
RORC P51449 1/20 0.43
MAPK14 Q16539 1/20 0.43
WNT3A P56704 2/20 0.42
MEN1 O00255 2/20 0.41
PRKACA P17612 1/20 0.41
ROCK1 Q13464 1/20 0.41
EGFR P00533 2/20 0.41
ERBB2 P04626 2/20 0.41
CACNA1H O95180 1/20 0.40
LMNA P02545 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
RAB9A P51151 1/20 0.40
MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12840473 0.95 KMT2A (0.50) KMT2ATP53WNT3AMEN1PRKACA
SCHEMBL12838523 0.92 KMT2A (0.47) KMT2ATP53THRBMAPTRORC
SCHEMBL12840420 0.91 KMT2A (0.47) KMT2AWNT3AMEN1PRKACAROCK1
SCHEMBL12839104 0.91 KMT2A (0.47) KMT2AWNT3AMEN1PRKACAROCK1
SCHEMBL12839102 0.91 RORC (0.44) KMT2ATP53RORCMEN1ROCK1
SCHEMBL12840437 0.90 KMT2A (0.46) KMT2ATHRBWNT3AMEN1PRKACA
SCHEMBL12839069 0.90 KMT2A (0.46) KMT2AWNT3AMEN1PRKACAROCK1
SCHEMBL12840421 0.90 KMT2A (0.46) KMT2ATP53MAPK14WNT3AMEN1
SCHEMBL13068290 0.90 RORC (0.43) KMT2ATP53RORCMEN1RAB9A
SCHEMBL12840376 0.90 KMT2A (0.46) KMT2ARORCWNT3AMEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885TP53 3223/4885THRB 2831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.