SCHEMBL12840376

SCHEMBL12840376

CCCc1nc(-c2ccccc2)cnc1NC(=O)Cc1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.46
TMIGD3 P0DMS9 1/20 0.43
MEN1 O00255 4/20 0.43
RAB9A P51151 2/20 0.43
NPC1 O15118 1/20 0.43
NPY5R Q15761 1/20 0.43
WNT3A P56704 3/20 0.42
RORC P51449 2/20 0.42
TSHR P16473 1/20 0.42
ALDH1A1 P00352 2/20 0.42
POLB P06746 1/20 0.42
HPGD P15428 1/20 0.42
CSNK1D P48730 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ELOVL1 Q9BW60 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839932 0.91 KMT2A (0.47) KMT2ATMIGD3MEN1RAB9ANPC1
SCHEMBL12839102 0.91 RORC (0.44) KMT2AMEN1RAB9ANPC1RORC
SCHEMBL12840363 0.90 KMT2A (0.46) KMT2ATMIGD3MEN1RAB9ANPC1
SCHEMBL12839000 0.90 KMT2A (0.47) KMT2ATMIGD3MEN1RAB9ANPC1
SCHEMBL12840474 0.90 KMT2A (0.46) KMT2AMEN1RAB9AWNT3ARORC
SCHEMBL13068290 0.90 RORC (0.43) KMT2AMEN1RAB9ANPC1RORC
SCHEMBL12840371 0.89 TMIGD3 (0.43) KMT2ATMIGD3MEN1RAB9ANPC1
SCHEMBL12840361 0.89 TMIGD3 (0.43) KMT2ATMIGD3MEN1RAB9ANPC1
SCHEMBL12840364 0.89 KMT2A (0.45) KMT2ATMIGD3MEN1RAB9ANPC1
SCHEMBL12839635 0.88 MEN1 (0.50) KMT2AMEN1RAB9ANPC1WNT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885TMIGD3 1782/4885MEN1 3926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.