SCHEMBL12840593

SCHEMBL12840593

COc1ccc2c(c1)CCc1nc(NC(=O)c3ccccc3)c(/C=C/c3ccccc3)nc1-2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 12/20 0.51
ALDH1A1 P00352 7/20 0.51
KDM4E B2RXH2 5/20 0.51
RAB9A P51151 4/20 0.51
MEN1 O00255 4/20 0.51
KMT2A Q03164 4/20 0.51
NPC1 O15118 3/20 0.51
HPGD P15428 3/20 0.51
APAF1 O14727 2/20 0.51
SMN1; SMN2 Q16637 8/20 0.49
TP53 P04637 4/20 0.48
SNCA P37840 2/20 0.48
LMNA P02545 4/20 0.47
GAA P10253 1/20 0.47
HTT P42858 1/20 0.47
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13068167 0.92 MAPT (0.48) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12840618 0.89 MAPT (0.46) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL13068102 0.88 MAPT (0.52) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12840655 0.88 SNCA (0.48) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12840656 0.87 SMN1; SMN2 (0.43) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12838634 0.87 MIF (0.44) MAPTKDM4ERAB9ANPC1HPGD
SCHEMBL12840616 0.86 RAB9A (0.43) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12840615 0.86 MAPT (0.43) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12838760 0.86 SRD5A1 (0.40) MAPTALDH1A1KDM4ERAB9AMEN1
SCHEMBL12839260 0.86 SNCA (0.45) MAPTALDH1A1KDM4ERAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 MAPT 3847/4885ALDH1A1 4516/4885KDM4E 4699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.