SCHEMBL12839260

SCHEMBL12839260

O=C(Nc1nc2c(nc1/C=C/c1ccccc1)-c1ccc(F)cc1CC2)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 2/20 0.45
SRD5A1 P18405 1/20 0.40
SRD5A2 P31213 1/20 0.40
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
HTT P42858 1/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
PPARG P37231 1/20 0.38
NCOA2 Q15596 1/20 0.38
NCOA1 Q15788 1/20 0.38
NCOA3 Q9Y6Q9 1/20 0.38
KDR P35968 5/20 0.38
GAA P10253 1/20 0.38
CYP2C19 P33261 1/20 0.38
LRRK2 Q5S007 1/20 0.38
HDAC1 Q13547 1/20 0.37
ALOX5 P09917 1/20 0.37
DHODH Q02127 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12840573 0.90 ADORA3 (0.38) SNCASRD5A1SRD5A2CYP1A2CYP3A4
SCHEMBL12838634 0.89 MIF (0.44) SNCASRD5A1SRD5A2CYP1A2CYP3A4
SCHEMBL12838760 0.88 SRD5A1 (0.40) SNCASRD5A1SRD5A2CYP1A2CYP3A4
SCHEMBL12839713 0.88 CYP1A2 (0.49) SNCASRD5A1SRD5A2CYP1A2CYP3A4
SCHEMBL12840226 0.86 CYP1A2 (0.39) CYP1A2CYP3A4HTTKDM4EALDH1A1
SCHEMBL12840593 0.86 MAPT (0.51) SNCACYP1A2CYP3A4HTTKDM4E
SCHEMBL12840648 0.85 RAB9A (0.44) KDM4EALDH1A1HDAC1NPC1RAB9A
SCHEMBL12840574 0.85 ALOX5 (0.41) SNCASRD5A1SRD5A2MAPTGAA
SCHEMBL13067876 0.85 PAX3 (0.39) SNCASRD5A1SRD5A2KDM4EMAPT
SCHEMBL12840649 0.84 RAB9A (0.39) ALDH1A1GAAHDAC1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 SNCA 4449/4885SRD5A1 4117/4885SRD5A2 4356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.