Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 14/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BMX | P51813 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16907738 | 0.82 | ALDH1A1 (0.47) | GPX4PDE4BBTKKMT2ANPC1 | |
| SCHEMBL20144240 | 0.77 | GPX4 (0.41) | GPX4PDE4BBTKKMT2ANPC1 | |
| SCHEMBL17616668 | 0.77 | BTK (0.40) | GPX4PDE4BBTKKMT2ANPC1 | |
| SCHEMBL15474336 | 0.77 | CYP2D6 (0.47) | GPX4PDE4BBTKKMT2ANPC1 | |
| SCHEMBL20892941 | 0.77 | BTK (0.39) | GPX4BTKKMT2AMEN1 | |
| SCHEMBL17033931 | 0.76 | GPX4 (0.45) | GPX4PDE4BBTKKMT2AMEN1 | |
| SCHEMBL32667371 | 0.76 | — | — | |
| SCHEMBL20892975 | 0.75 | BTK (0.36) | BTK | |
| SCHEMBL20892899 | 0.74 | ALDH1A1 (0.43) | GPX4PDE4BBTKKMT2ANPC1 | |
| SCHEMBL19353399 | 0.74 | ALDH1A1 (0.43) | GPX4PDE4BBTKKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034907-A2 | PROTEIN KINASE CONJUGATES AND INHIBITORS | AVILA THERAPEUTICS, INC. (US) | 2011-03-24 | — | — | WO | disclosed |