Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363834 | 0.82 | MAP4K4 (0.41) | PSMB8STK17BMAP4K4CYP17A1ATR | |
| SCHEMBL8363843 | 0.79 | MAPT (0.42) | PSMB8STK17BRAB9AMEN1MAPT | |
| SCHEMBL15081348 | 0.78 | MAPK1 (0.46) | MAP4K4MEN1MAPTMAPK1KMT2A | |
| SCHEMBL25736547 | 0.70 | ALDH1A1 (0.44) | CYP17A1CA12CA1CA9MAPK1 | |
| SCHEMBL13885934 | 0.70 | CYP17A1 (0.50) | PSMB8MAP4K4CYP17A1CA12CA1 | |
| SCHEMBL8363848 | 0.69 | PSMB8 (0.34) | PSMB8MAP4K4MAPK1 | |
| SCHEMBL13633012 | 0.69 | CYP17A1 (0.40) | CYP17A1ATRRAB9AMETAP1MEN1 | |
| SCHEMBL25736549 | 0.69 | CYP17A1 (0.45) | CYP17A1RAB9AMETAP1MEN1MAPT | |
| SCHEMBL24908194 | 0.68 | CYP17A1 (0.50) | CYP17A1CA12CA1CA9MEN1 | |
| SCHEMBL18966274 | 0.67 | CA12 (0.42) | PSMB8MAP4K4CYP17A1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902223-B2 | For therapy and prophylaxis of thromboses, myocardial infarction, arteriosclerosis, inflammation, apoplexia, angina pectoris, restenosis after angioplasty, claudicatio intermittens, migraine, tumours, tumour diseases and/or tumour metastases | MERCK PATENT GMBH (DE) | 2011-03-08 | — | — | US | disclosed |