Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.61 |
| ▸ | AXL | P30530 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | APP | P05067 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217147 | 0.79 | HTT (0.66) | MAPTDYRK1AAPPSULT1A1GAA | |
| SCHEMBL9255622 | 0.79 | GFER (0.66) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL3644141 | 0.78 | PDPK1 (0.55) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL1639031 | 0.78 | GFER (0.63) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL369984 | 0.76 | GFER (0.61) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL7005689 | 0.76 | GFER (0.61) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL7700068 | 0.76 | GFER (0.61) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL2615304 | 0.76 | SMN1; SMN2 (0.61) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL2615303 | 0.76 | SMN1; SMN2 (0.61) | GFERAXLMAPTKDM4EALDH1A1 | |
| SCHEMBL7222746 | 0.76 | GFER (0.61) | GFERAXLMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059047-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059047-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, ZC3HAV1 | GFER 4345/4885AXL 3631/4885MAPT 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.