Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.39 |
| ▸ | RELA | Q04206 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12796916 | 0.86 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL12848861 | 0.81 | NPC1 (0.54) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL12848862 | 0.80 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL12796353 | 0.74 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9ATP53MAPT | |
| SCHEMBL12796748 | 0.72 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL12848575 | 0.71 | LDLR (0.42) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL12796755 | 0.71 | CD38 (0.48) | SMN1; SMN2NPC1RAB9ATP53RORC | |
| SCHEMBL3219333 | 0.71 | MAPK14 (0.62) | SMN1; SMN2NPC1RAB9ATP53MAPT | |
| SCHEMBL12796652 | 0.70 | MAPT (0.66) | SMN1; SMN2NPC1RAB9ATP53MAPT | |
| SCHEMBL14172713 | 0.70 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9ATP53RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052643-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052643-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | TSLP, NFATC1, IL5 | SMN1; SMN2 4820/4885NPC1 1042/4885RAB9A 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.