Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12798144 | 0.84 | AGTR2 (0.54) | HTR2CAGTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8351858 | 0.84 | AGTR2 (0.54) | HTR2CAGTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7646821 | 0.84 | AGTR2 (0.54) | HTR2CAGTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16276273 | 0.83 | HTR2C (0.49) | HTR2CCACNA1GCACNA1HCACNA1IAGTR2 | |
| SCHEMBL13613246 | 0.82 | HTR2C (0.48) | HTR2CAGTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25125018 | 0.81 | HTR2C (0.61) | HTR2CCACNA1GCACNA1HCACNA1IAGTR2 | |
| SCHEMBL25196217 | 0.81 | HTR2C (0.55) | HTR2CCACNA1GCACNA1HCACNA1IAGTR2 | |
| SCHEMBL13910588 | 0.80 | TACR3 (0.47) | HTR2CAGTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13613244 | 0.80 | AGTR2 (0.50) | HTR2CAGTR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29492496 | 0.80 | HTR2C (0.53) | HTR2CCACNA1GCACNA1HCACNA1IAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906550-B2 | Viricide against hepatitis virus; pyrrole derivatives as, for example, 3-acetyl-4,5-dimethyl-2-pyrrole carboxylic acid | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-15 | — | — | US | disclosed |
| US-20090291902-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-26 | — | — | US | disclosed |
| US-20080125376-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291902-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE | PRSS1, SERPINB1, SPINT2 | HTR2C 2850/4885CACNA1G 4756/4885CACNA1H 4775/4885 |
| US-20080125376-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE | PRSS1, SERPINB1, SPINT2 | HTR2C 2801/4885CACNA1G 4737/4885CACNA1H 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.