Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PAH | P00439 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15185758 | 0.87 | TYMS (0.43) | NOS1XDHNOS3NOS2USP2 | |
| SCHEMBL156195 | 0.69 | KDM4E (0.57) | NOS1NOS3NOS2USP2CASP7 | |
| Hydrochloric Acid SCHEMBL625929 | 0.67 | KDM4E (0.59) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL12368142 | 0.62 | TYMS (0.47) | XDHHSD17B10KDM4EMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL10803149 | 0.62 | PAH (0.42) | NOS1XDHNOS3NOS2USP2 | |
| SCHEMBL584982 | 0.61 | NOS1 (0.64) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL10506793 | 0.61 | TYMS (0.40) | XDHKDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL7515343 | 0.60 | TYMS (0.42) | XDHMAPTKMT2ANPSR1TDP1 | |
| Hydrochloric Acid SCHEMBL16741181 | 0.60 | NOS1 (0.62) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL1860432 | 0.59 | NOS1 (1.00) | NOS1NOS3NOS2USP2CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906520-B2 | Reducing expression of tetrahydrobiopterin (BH4) biological activity; traumatic, metabolic or toxic peripheral nerve lesions | THE GENERAL HOSPITAL CORPORATION (US) | 2011-03-15 | — | — | US | disclosed |