Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 13/20 | 1.00 |
| ▸ | NOS3 | P29474 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.44 |
| ▸ | PAH | P00439 | 1/20 | 0.41 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860433 | 0.78 | NOS1 (0.64) | NOS1NOS3QTRT1 | |
| SCHEMBL4323780 | 0.76 | NOS1 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL584982 | 0.74 | NOS1 (0.64) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL19410958 | 0.73 | NOS1 (0.59) | NOS1NOS3NOS2USP2CASP7 | |
| Hydrochloric Acid SCHEMBL16741181 | 0.73 | NOS1 (0.62) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL2044797 | 0.71 | NOS1 (0.78) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL3799967 | 0.70 | NOS1 (0.66) | NOS1NOS3NPSR1 | |
| SCHEMBL9248337 | 0.69 | NOS1 (0.72) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL4649233 | 0.69 | NOS1 (0.72) | NOS1NOS3NOS2USP2CASP7 | |
| SCHEMBL4649231 | 0.69 | NOS1 (0.72) | NOS1NOS3NOS2USP2CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119925601-A | Application of tetrahydrobiopterin pathway as target in anti-QDPR deletion type tumor | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2025-05-06 | — | — | CN | claimed |
| WO-2024084421-A1 | TREATMENT OF VASCULAR DISEASES ASSOCIATED WITH GENETIC VARIATIONS IN ACTA2 | QRGENETICS LTD. (IL) | 2024-04-25 | — | — | WO | claimed |
| WO-2019175328-A1 | BH4PATHWAYACTIVATIONANDUSETHEREOFFORTREATINGCANCER | IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH (AT) | 2019-09-19 | — | — | WO | claimed |
| US-20110104137-A1 | ADJUNCTS AND COMPLEXES FOR IMPROVING HMG-CoA REDUCTASE INHIBITOR (STATIN) AND SELECTIVE PHOSPHODIESTERASE 5 INHIBITOR THERAPY | CHRONORX LLC, AN ALASKA LIMITED LIABILITY COMPANY (US) | 2011-05-05 | — | — | US | claimed |
| US-20090068264-A1 | Clinical Applications of Tetrahydrobiopterin, Lipoic Acid and Their Salts and Methods of Preparing Tetrahydrobiopterin Bis-Lipoate | CHRONORX LLC (US) | 2009-03-12 | — | — | US | claimed |
| US-20080221111-A1 | Roflumilast and sepiapterin; (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; prevention, treatment of respiratory diseases | NYCOMED GMBH (DE) | 2008-09-11 | — | — | US | claimed |
| EP-1940392-A2 | COMBINATION OF THE PDE4 INHIBITOR AND A TETRAHYDROBIOPTERIN DERIVATIVE | Nycomed GmbH (DE) | 2008-07-09 | — | — | EP | claimed |
| WO-2006120176-A2 | COMBINATION OF THE PDE4 INHIBITOR ROFLUMILAST AND A TETRAHYDROBIOPTERIN DERIVATIVE | NYCOMED GMBH (DE) | 2006-11-16 | — | — | WO | claimed |
| US-20060194808-A1 | Clinical applications of tetrahydrobiopterin, lipoic acid and their salts and methods of preparing tetrahydrobiopterin bis-lipoate | CHRONORX LLC, AN ALASKA LIMITED LIABILITY COMPANY (US) | 2006-08-31 | — | — | US | claimed |
| WO-2005018620-A2 | USE OF NITRIC OXIDE SYNTHASE (NOS) COFACTOR FOR THE TREATMENT OF SEXUAL DYSFUNCTION | CELL CENTER COLOGNE GMBH (DE) | 2005-03-03 | — | — | WO | claimed |
| US-20250255873-A1 | RESTORING FUNCTION OF SPECIFIC MUTATIONS AFFECTING THE ACTIN DYNAMIC BY ADMINISTRATION OF SAPROPTERIN | QRGENETICS LTD. (IL) | 2025-08-14 | — | — | US | disclosed |
| WO-2024084421-A1 | TREATMENT OF VASCULAR DISEASES ASSOCIATED WITH GENETIC VARIATIONS IN ACTA2 | QRGENETICS LTD. (IL) | 2024-04-25 | — | — | WO | disclosed |
| WO-2019175328-A1 | BH4PATHWAYACTIVATIONANDUSETHEREOFFORTREATINGCANCER | IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH (AT) | 2019-09-19 | — | — | WO | disclosed |
| EP-2813509-B1 | 3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinoline derivatives | ASTRAZENECA AB (SE) | 2017-02-01 | — | — | EP | disclosed |
| US-9492451-B2 | Stable compositions of tetrahydrobiopterin | DIPHARMA S.A. (CH) | 2016-11-15 | — | — | US | disclosed |
| EP-0722731-A1 | REMEDY FOR SPINOCEREBELLAR DEGENERATION | SUNTORY LIMITED (JP) | 1996-07-24 | — | — | EP | disclosed |
| EP-0209689-B1 | USE OF TETRAHYDROBIOPTERINS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF INFANTILE AUTISM | SUNTORY LIMITED (JP) | 1992-03-11 | — | — | EP | disclosed |
| US-4920122-A | TETRAHYDROBIOPTERIN, 5-HYDROXYTRYPTOPHAN AND L-DOPA MIXTURE | SUNTORY LIMITED (JP) | 1990-04-24 | — | — | US | disclosed |
| US-4778794-A | TETRAHYDROBIOPTERIN OR DERIVATIVE | SUNTORY LIMITED (JP) | 1988-10-18 | — | — | US | disclosed |
| EP-0209689-A2 | Use of tetrahydrobiopterins in the preparation of a medicament for the treatment of infantile autism | SUNTORY LIMITED (JP) | 1987-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110104137-A1 | ADJUNCTS AND COMPLEXES FOR IMPROVING HMG-CoA REDUCTASE INHIBITOR (STATIN) AND SELECTIVE PHOSPHODIESTERASE 5 INHIBITOR THERAPY | HMGCR, CYP11A1, PDE5A | NOS1 754/4885NOS3 597/4885NOS2 839/4885 |
| US-20250255873-A1 | RESTORING FUNCTION OF SPECIFIC MUTATIONS AFFECTING THE ACTIN DYNAMIC BY ADMINISTRATION OF SAPROPTERIN | ACTR2, ACTB, ACTR3 | NOS1 2695/4885NOS3 3271/4885NOS2 1672/4885 |
| US-20080221111-A1 | Roflumilast and sepiapterin; (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; prevention, treatment of respiratory diseases | SPR, PAH, QDPR | NOS1 264/4885NOS3 173/4885NOS2 293/4885 |
| US-20090068264-A1 | Clinical Applications of Tetrahydrobiopterin, Lipoic Acid and Their Salts and Methods of Preparing Tetrahydrobiopterin Bis-Lipoate | BPHL, RBP4, GLS | NOS1 445/4885NOS3 597/4885NOS2 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.