Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 18/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12747714 | 0.85 | HTR7 (0.47) | HTR7LTB4R | |
| SCHEMBL12747735 | 0.84 | HTR7 (0.46) | HTR7LTB4R | |
| SCHEMBL12747713 | 0.81 | LTB4R (0.56) | HTR7LTB4R | |
| SCHEMBL12747734 | 0.80 | LTB4R (0.57) | HTR7LTB4R | |
| SCHEMBL12747744 | 0.77 | HTR7 (0.44) | HTR7LTB4R | |
| SCHEMBL23364685 | 0.75 | HTR7 (0.63) | HTR7LTB4RCDK9DYRK1ADYRK2 | |
| SCHEMBL29932740 | 0.75 | HTR7 (0.63) | HTR7LTB4RCDK9DYRK1ADYRK2 | |
| SCHEMBL24741781 | 0.74 | CA12 (0.50) | HTR7 | |
| SCHEMBL31637930 | 0.74 | HTR7 (0.51) | HTR7CDK9DYRK1ADYRK2 | |
| SCHEMBL12747743 | 0.72 | HTR7 (0.47) | HTR7LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480554-B1 | MACROCYCLIC INHIBITORS OF JAK | HOFFMANN LA ROCHE (CH) | 2014-08-06 | — | — | EP | disclosed |
| WO-2011033053-A1 | MACROCYCLIC INHIBITORS OF JAK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |