Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285100 | 1.00 | BRAF (0.42) | BRAFMAP3K5HDAC3HDAC2SHMT2 | |
| SCHEMBL1285305 | 0.93 | HDAC3 (0.41) | BRAFMAP3K5HDAC3HDAC2KDM4E | |
| SCHEMBL1285304 | 0.93 | HDAC3 (0.41) | BRAFMAP3K5HDAC3HDAC2KDM4E | |
| SCHEMBL1284412 | 0.92 | HDAC3 (0.40) | MAP3K5HDAC3HDAC2KDM4ETRPV1 | |
| SCHEMBL1285679 | 0.92 | HDAC3 (0.40) | MAP3K5HDAC3HDAC2KDM4ETRPV1 | |
| SCHEMBL1644317 | 0.91 | BRAF (0.41) | BRAFHDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL1646258 | 0.91 | HDAC3 (0.50) | HDAC3HDAC2ALDH1A1KDM4ELMNA | |
| SCHEMBL1285568 | 0.91 | PTGER4 (0.39) | BRAFHDAC3HDAC2PIK3CA | |
| SCHEMBL1285566 | 0.91 | PTGER4 (0.39) | BRAFHDAC3HDAC2PIK3CA | |
| SCHEMBL1284636 | 0.90 | HDAC3 (0.42) | BRAFHDAC3HDAC2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | BRAF 2721/4885MAP3K5 1499/4885HDAC3 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.